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The research protocol was accepted through the College of Michigan and Harper Medical center human-study committees. The patients ended up interviewed around the working day of their initial evaluations inside the cardiac-surgical procedure outpatient clinic. The sufferers who consented were being randomly assigned in the double-blind trend to start oral therapy on the same working day. Individuals had been enrolled a mean (±SD) of 13±seven times before surgical treatment. Amiodarone (Cordarone, Wyeth–Ayerst Laboratories, Philadelphia) was prescribed at a dosage of 1 pill (two hundred mg) three times a day for 7 days, then just one pill on a daily basis though the affected individual was hospitalized.
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The use of prophylactic oral amiodarone for a minimum of a single week ahead of elective coronary heart operation minimized the incidence of postoperative atrial fibrillation by roughly fifty %, considerably decreased the length and full cost of hospitalization, and decreased the number of symptomatic episodes of atrial fibrillation developing right after discharge.
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